Novel Insights into Genetic Approaches in Glioblastoma Multiforme Therapy

Glioblastoma multiforme is one of the most common and malignant types central nervous system (CNS) tumors. Despite great advances in treatment modalities variety therapeutic options, it remains largely incurable with continuously growth incidence, due to genomic instability glioblastoma cells, their heterogeneity, resistance chemo- radiotherapies. The aggressive behavior these brain tumors sequestered location behind blood–brain barrier restricts role immune system. Great success has been made recently using genetic based approaches selectively target cancerous cells restore tumor suppressor gene expression or silence specific oncogenes prevent expression. use attracted more interest research revealed ability regulate without changing genotype thus avoiding possible genotoxicity. This review delivers an overview cell biology, tumorigenesis, surveillance, discusses recent therapies multiforme.